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Available over-the-counter, antacids create a basic chemical reaction that partially neutralizes stomach acid to provide relatively rapid and short-term relief for heartburn, sour stomach and acid indigestion. Antacids are best for occasional, relatively mild cases of heartburn that can be attributed to a specific event or behavior, such as overeating at a holiday dinner or eating spicy foods.

Indications: Relieves sour stomach, heartburn and acid indigestion.

Available at Costco: Kirkland Signature™ Ultra Strength Antacid Calcium Carbonate 1000 mg

Bismuth Subsalicylate

This coats the esophagus and acts as a barrier to refluxed gastric acid. Used to relieve upset stomach, indigestion, diarrhea, nausea, gas, fullness and heartburn, bismuth subsalicylates are available over-the-counter for occasional use and quick, temporary relief.

Indications: Relieves upset stomach due to overindulgence in food and drink, travelers´┐Ż diarrhea and diarrhea.

H2 Blockers and Histamine Receptor Antagonists

These partially block production of acid in the stomach cells by inhibiting histamine, a substance that stimulates secretion of stomach acid. Over-the-counter and prescription H2 blockers relieve heartburn associated with acid indigestion and sour stomach and prevent meal-induced heartburn. These acid reducers generally relieve symptoms for a longer period of time than antacids, but take time to work initially. Over-the-counter H2 blockers include Ranitidine (brand name: Zantac®) and Famotidine (brand name: Pepcid®).

Prescription H2 blockers may provide short-term treatment of symptomatic gastroesophageal reflux disease (GERD) and, with longer duration and higher daily dosages, relief of erosive esophagitis.

Indications: Relieves heartburn associated with acid indigestion and sour stomach; also appropriate as a preventive heartburn measure when taken at least an hour before a meal.

Available at Costco: Kirkland Signature™ Acid Reducer Maximum Strength Ranitidine 150 mg, Kirkland Signature™ Maximum Strength Acid Controller Famotidine 20 mg

Proton Pump Inhibitors (PPIs)

PPIs, the newest class of heartburn medications, actually deactivate the pumps in the stomach lining from producing acid, significantly inhibiting acid production (and its overproduction) at the source. PPIs are available over-the-counter or as a prescription to treat ulcers, gastroesophageal reflux disease (GERD) and erosive esophagitis. PPIs include store-brand Omeprazole (treats the same symptoms as Prilosec OTC®) and Lansoprazole (treats the same symptoms as Prevacid® 24HR), to treat frequent heartburn that occurs two or more days per week. These products may take 1 to 4 days to work initially and are not indicated for immediate relief of frequent heartburn. Over-the-counter PPIs such as Omeprazole and Lansoprazole should be used as a 14-day course of treatment every four months. You should not take PPIs for more than 14 days unless directed by your doctor.

Indications: Treats frequent heartburn occurring two or more days a week.

Available at Costco: Kirkland Signature™ Omeprazole 20 mg Delayed Release Tablets, Kirkland Signature™ Lansoprazole 15 mg Delayed-Release Capsules